IMMUNOMODULATORY ACTIVITY OF ANTIMICROBIAL PEPTIDE INDOLICIDIN AND ITS STRUCTURAL ANALOGUES
نویسندگان
چکیده
منابع مشابه
Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues.
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Mode of action of the antimicrobial peptide indolicidin.
Indolicidin is a cationic antimicrobial peptide isolated from bovine neutrophils. It consists of only 13 amino acids, has the highest tryptophan content of any known protein, and is amidated at the carboxyl terminus in nature. By circular dichroism spectroscopy a weak poly-L-proline II extended helix structure was observed that became substantially more pronounced upon interaction with liposome...
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Indolicidin is a tridecapeptide amide isolated from the cytoplasmic granules of bovine neutrophils. It has potent, broad spectrum microbicidal activities in vitro that are thought to be related to the membrane-disruptive properties of the peptide. Based on the putative membrane-targeted mode of action, we postulated that indolicidin would be active against HIV-1, an enveloped virus. Indolicidin...
متن کاملEffect of Antimicrobial Peptide-Amide: Indolicidin on Biological Membranes
Indolicidin, a cationic antimicrobial tridecapeptide amide, is rich in proline and tryptophan residues. Its biological activity is intensively studied, but the details how indolicidin interacts with membranes are not fully understood yet. We report here an in situ atomic force microscopic study describing the effect of indolicidin on an artificial supported planar bilayer membrane of dipalmitoy...
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ژورنال
عنوان ژورنال: Medical Immunology (Russia)
سال: 2014
ISSN: 2313-741X,1563-0625
DOI: 10.15789/1563-0625-2009-1-101-104